Deep brain stimulation emerging indications.
Identifieur interne : 001693 ( Main/Exploration ); précédent : 001692; suivant : 001694Deep brain stimulation emerging indications.
Auteurs : Travis S. Tierney [Canada] ; Tejas Sankar ; Andres M. LozanoSource :
- Progress in brain research [ 1875-7855 ] ; 2011.
English descriptors
- KwdEn :
- Alzheimer Disease (physiopathology), Alzheimer Disease (therapy), Animals, Brain (anatomy & histology), Brain (physiology), Brain (physiopathology), Cerebrovascular Circulation, Deep Brain Stimulation (instrumentation), Deep Brain Stimulation (methods), Depressive Disorder, Treatment-Resistant (physiopathology), Depressive Disorder, Treatment-Resistant (therapy), Electrodes, Implanted, Humans, Parkinson Disease (physiopathology), Parkinson Disease (therapy), Regional Blood Flow.
- MESH :
- anatomy & histology : Brain.
- instrumentation : Deep Brain Stimulation.
- methods : Deep Brain Stimulation.
- physiology : Brain.
- physiopathology : Alzheimer Disease, Brain, Depressive Disorder, Treatment-Resistant, Parkinson Disease.
- therapy : Alzheimer Disease, Depressive Disorder, Treatment-Resistant, Parkinson Disease.
- Animals, Cerebrovascular Circulation, Electrodes, Implanted, Humans, Regional Blood Flow.
Abstract
There are a number of emerging surgical indications for deep brain stimulation. We have shown that modulation of activity within motor, mood, and cognitive circuits has beneficial effects in patients with Parkinson's disease, treatment-resistant depression, and perhaps Alzheimer's type dementia. We review the rationale, safety, and efficacy for each of these indications, focusing on disease mechanisms and relevant data that are necessary to document therapeutic value in each case. The review closes with some thoughts on possible future directions for deep brain stimulation. It is likely that applications for deep brain stimulation will continue to expand as accumulating data establish its safety and efficacy profile in these and other conditions.
DOI: 10.1016/B978-0-444-53815-4.00015-7
PubMed: 21867796
Affiliations:
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Le document en format XML
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Tierney</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Sankar, Tejas" sort="Sankar, Tejas" uniqKey="Sankar T" first="Tejas" last="Sankar">Tejas Sankar</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></author></analytic><series><title level="j">Progress in brain research</title><idno type="eISSN">1875-7855</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (physiopathology)</term><term>Alzheimer Disease (therapy)</term><term>Animals</term><term>Brain (anatomy & histology)</term><term>Brain (physiology)</term><term>Brain (physiopathology)</term><term>Cerebrovascular Circulation</term><term>Deep Brain Stimulation (instrumentation)</term><term>Deep Brain Stimulation (methods)</term><term>Depressive Disorder, Treatment-Resistant (physiopathology)</term><term>Depressive Disorder, Treatment-Resistant (therapy)</term><term>Electrodes, Implanted</term><term>Humans</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Regional Blood Flow</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Alzheimer Disease</term><term>Brain</term><term>Depressive Disorder, Treatment-Resistant</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Alzheimer Disease</term><term>Depressive Disorder, Treatment-Resistant</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cerebrovascular Circulation</term><term>Electrodes, Implanted</term><term>Humans</term><term>Regional Blood Flow</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are a number of emerging surgical indications for deep brain stimulation. We have shown that modulation of activity within motor, mood, and cognitive circuits has beneficial effects in patients with Parkinson's disease, treatment-resistant depression, and perhaps Alzheimer's type dementia. We review the rationale, safety, and efficacy for each of these indications, focusing on disease mechanisms and relevant data that are necessary to document therapeutic value in each case. The review closes with some thoughts on possible future directions for deep brain stimulation. It is likely that applications for deep brain stimulation will continue to expand as accumulating data establish its safety and efficacy profile in these and other conditions.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name><name sortKey="Sankar, Tejas" sort="Sankar, Tejas" uniqKey="Sankar T" first="Tejas" last="Sankar">Tejas Sankar</name></noCountry><country name="Canada"><noRegion><name sortKey="Tierney, Travis S" sort="Tierney, Travis S" uniqKey="Tierney T" first="Travis S" last="Tierney">Travis S. Tierney</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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